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aquaeri in comments to this interesting post.
(PNAS++ for making the article available online. Oh, ah, they manage that by charging the authors $1000 to exercise the Open Access option. authors++)
What I got:
Still up in the air:
I'd love love love to see this paper's measurements of APC taken along
with ones of olfactory bulb. *That* could get you somewhere.
"single cortical neurons are likely to receive signals derived from combinations of ORs [cite]. Based on the findings presented here, we speculate that neurons in the OC require combinatorial OR signals for activation." --
That's reasonable speculation, but how is it based on these findings?
What is the shape of the APC?
Layers I, II, III shown in Fig 1 coronal sections, but what is their orientation?
Is APC your six-layer flavor of cortex? Where are IV+ in this picture? And does it have inhibitory interneurons and suchlike?
Fig 2 reducing APC to 2 dimensions -- collapsing away the lateral axis?
Can't figure out how layers would show up on Fig 2 maps.
Hierarchical clustering: "stimuli viewed as vector variables determined by number and distribution of c-Fos+ cells" -- well, heck, determined *how*? I say feh to the hierarchical clustering.
They slam the mouse with a lot of odorant and see every neuron light up. Would this identical measurement show up with a high concentration of a different odorant? I bet the *mouse* can tell overwhelming thiol from overwhelming ester.
aquaeri in comments to this interesting post.(PNAS++ for making the article available online. Oh, ah, they manage that by charging the authors $1000 to exercise the Open Access option. authors++)
What I got:
- A given odorant excites a widespread clumpy pattern over the anterior piriform cortex (APC).
- Similar odorants have similar patterns.
- Even different odorants have overlapping swathes. (I.e. they hit some neurons very near each other.)
Still up in the air:
- For all I can see here, the patterns in APC could be just scramblings of the clustered odorant responses seen in olfactory bulb.
- For example, do we know that any APC neuron receives inputs from two distinct receptor clones?
- When similar odorants have similar patterns in APC, is that simply because they light up similar sets of olfactory receptors upstream? (The authors mention this for future work.)
- Is there any kind of processing being done in APC?
- Does position within the APC mean anything?
I'd love love love to see this paper's measurements of APC taken along
with ones of olfactory bulb. *That* could get you somewhere.
"single cortical neurons are likely to receive signals derived from combinations of ORs [cite]. Based on the findings presented here, we speculate that neurons in the OC require combinatorial OR signals for activation." --
That's reasonable speculation, but how is it based on these findings?
What is the shape of the APC?
Layers I, II, III shown in Fig 1 coronal sections, but what is their orientation?
Is APC your six-layer flavor of cortex? Where are IV+ in this picture? And does it have inhibitory interneurons and suchlike?
Fig 2 reducing APC to 2 dimensions -- collapsing away the lateral axis?
Can't figure out how layers would show up on Fig 2 maps.
Hierarchical clustering: "stimuli viewed as vector variables determined by number and distribution of c-Fos+ cells" -- well, heck, determined *how*? I say feh to the hierarchical clustering.
They slam the mouse with a lot of odorant and see every neuron light up. Would this identical measurement show up with a high concentration of a different odorant? I bet the *mouse* can tell overwhelming thiol from overwhelming ester.
